InterXClinic InterX – Articles and publications

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 “Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption.” (2003), A meta-analysis with assessment of optimal treatment parameters for postoperative pain. Jan Magnus Bjordala,*, Mark I. Johnsonb, Anne Elisabeth Ljunggreena  (122KB)

 “NRG Sinusitus Study” (2008), The Effects of Treatment of an Interactive Cutaneous Neurostimulator on Recurrent Sinusitis. Gerhard Maale, MD Janice Walker, OTR  (3MB)

 “NRG Ankle Study” (2008), The effects of InterX treatment on Pain and Oedeme during Post Surgical Rehabilitation following Internal Fixation of Unstable Bimalleolar Ankle Fractures. I.G. Gorodetskyi, A.I. Gorodnichenko, P.S. Tursin, V.K. Reshetnyak, O.N. Uskov  (365KB)

 “The Skin as a Neuroimmunoendocrine Organ” (2004), Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ .  Dirk Roosterman, Tobias Goerge, Stefan W. Schneider, Nigel W. Bunnett and Martin Steinhoff  (124KB)

 “Neuropathic pain” (2004), Contemporary Management of Neuropathic Pain for the Primary Care Physician.  HSIUPEI CHEN, MD; TIM J. LAMER, MD; RICHARD H. RHO, MD; KENNETH A. MARSHALL, MD; B. TODD SITZMAN, MD; SALIM M. GHAZI, MD; AND RANDALL P. BREWER, MD  (124KB)

 “Mechanisms of TENS” (2003), Transcutaneous ElectricalNerve Stimulation: Basic Science Mechanismsand Clinical Effectiveness. Kathleen A. Sluka* and Deirdre Walsht  (1132KB)

 “MCL Sheep study abstract” (2010), Non-invasive Interactive Neurostimulation (InterX ) as an adjunct in pain control for patients following Total Knee and Total Hip Arthroplasty: a Randomized Placebo Controlled Trial. A. Pedadda, MD G. Maale, MD (99KB)

 “Knee Hip poster” (2010), Non-invasive Interactive Neurostimulation (InterX ) as an adjunct in pain control for patients following Total Knee and Total Hip Arthroplasty: a Randomized Placebo Controlled Trial. A. Pedadda, MD G. Maale, MD (863KB)

 “InterX vs TENS Poster” (1.6MB)

 “InterX vs TENS” (2010), NON-INVASIVE INTERACTIVE NEUROSTIMULATION (INTERX®) ELICITS SIGNIFICANTLY GREATER PHYSIOLOGICAL RESPONSE THAN TENS: LYMPHOCYTE METABOLISM AND CYTOKINE PRODUCTION . Gail Pyne-Geithman, D.Phil.*, Joseph F. Clark, Ph.D. (191KB)

 “IASP 2010 – LBP InterX Clinic“(2010), INTERX DEVICE FOR THE TREATMENT OF CHRONIC INTRACTABLE LOW BACK PAIN: A PILOT STUDY. Janice Walker OTR, Dr Zulia Valeyeva Frost MD. (195KB)

 “IASP 2010 – CRPS-MKTG-020“(2010), INTERX THERAPY, A NEW APPROACH TO TREATING CRPS: A CASE HISTORY. Complex regional pain syndrome is described as a disease of the autonomic nervous system. Janice Walker OTR, Paul Magee (306KB)

 “Bruise case study“(2009), InterX Therapy was applied 8 days after trauma. Two treatments were applied in the 24 hour period following the eighth day after initial trauma. (101KB)

 “Blood study” (2009), Changes in Lymphocyte Metabolism, Genexpression and Cytokine production following Transdermal Interactive Neurostimulation: indicators of Connective Tissue Healing and Anti-inflammatory activity (578KB)

 “InterX Brochure” (2008), by Dr. Zulia Valeyeva-Frost (354KB)

  “Cutaneous patterns of sympathetic activity in clinical abnormalities of the musculosceletal system” (1964), Irvin M.Korr, H.M.Wright, J.A. Chace (685KB)

  “The Evaluation of Electrodermal Properties in the Identification of Myofascial Trigger Points”, Sarah P. Shultz, MEd, Jeffrey B. Driban, MEd, Charles B. Swanik, PhD  (30KB)

  “An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle”, Jay P. Shah, Terry M. Phillips, Jerome V. Danoff and Lynn H. Gerber   (354KB)

  “Fall of Skin Impedance in Bone and Joint Pain”, Fujita Takuo, Fujii Yoshio…    (48KB)

  “A Cascade of cytokines mediates mechanical inflammatory hypernocyception in mice”, T.M.Cunha    (548KB)

  “The Effects of Non-Invasive Interactive Neurostimulation Therapy on Pain and Oedema during Post Surgical Rehabilitation following Internal Fixation of Unstable Bimalleolar Ankle Fractures”, I.G. Gorodetskyi, A.I. Gorodnichenko, P.S. Tursin, V.K. Reshetnyak, O.N. Uskov    (51KB)

  “Case Study – Reflex Sympathetic Dystrophy(RSD)/Complex Regional Pain Syndrome(CRPS)”, NRG   (763KB)

 IASP 2010 – Abstract  PPH TKR, InterX as an adjunct for pain control in patients following total knee replacement, Dr Ashok K.Nigam, Dr Zulia-Valayeva Frost, Drena Taylor (326KB)

 “IASP 2010 – InterX Hip Abstract”, InterX as an adjunct for pain control in patients following total hip replacement, Dr. Arvind V Peddada, Dr Gerhard Maale (364KB)

 “IASP 2010 – InterX Knee Abstract”, InterX as an adjunct for pain control in patients following total knee arthroplasty, Dr. Arvind V Peddada, Dr Gerhard Maale (374KB)

 “IASP Abstract 2010 – InterX vs Baseline”, Changes in lymphocyte metabolism, gene expression and cytokine production following transdermal interactive neurostimulation(InterX), Gail Pyne-Geithman, Joseph F. Clark, Paul Magee (359KB)

 

REFERENCE LITERATURE 
Non- Invasive Interactive Neurostimulation – (NIN) – InterX therapy

 

Criteria-Based Management of an Acute Multistructure Knee Injury in a Professional Football Player” A.J. Yenchak PT DPT CSCS, Kevin E Wilk PT DPT, Christopher A Arrigo PT MS, Charles D Simpson II PT DPT CSCS, James R Andrews MD. Journal of orthopaedic & sports physical therapy. Vol 41, Number 9, Sept 2011  Knee injury professional football player A Case Report

Results of a RCT using non-invasive interactive neurostimulation in the post-surgical recovery of patients with trochanteric fracture of the femur”. Gorodnichenko A.I., MD, Gorodetskyi I.G., Ph.D. Department of Traumatology and Orthopaedics, Scientific Educational Medical Centre, Federal Government Institution of the President of the Russian Federation, Moscow, RU. Journal of Bone and Joint Surgery – British Volume, Vol 89-B, Issue 11, 1488-1494 2007.http://www.jbjs.org.uk/cgi/content/abstract/89-B/11/1488

Changes in Lymphocyte Metabolism, Gene Expression and Cytokine production following Transdermal Interactive Neurostimulation:indicators of Connective Tissue Healing and Anti-inflammatory activity” Joseph F.Clark, ATC, PhD. Gail Pyne-Geithman, D Phil Department of Neurology, University of Cincinnati, OH 45267-0536, USA. Read article…

New physiological study defining the difference between the InterX and electro stimulation technologies has been carried out at the University of Cincinnati. These initial findings have provided some extremely valuable data as we continue our research into the mechanism of action and physiological effects of InterX Therapy. It explains the impact on the immune system and reparative mechanisms. Read abstract article…

Influence of Neurostimulation in a Transected Medial Collateral Ligament in Sheep”.  Bill Walsh, DirectorSurgical & Orthopaedic Research Laboratories, University of New South Wales. ” Reported at the 6th Combined Meeting of the Orthopaedic Research Societies, October 2007, Honolulu, Hawaii. Read abstract article…

“The effects of a handheld, cutaneous, portable, neuro stimulator in patients with chronic severe orthopedic pain.” Maale G, Gamez M. [poster]  18th Annual Symposium of the International Society for Technology in Arthroplasty, Kyoto, Japan 2005.  [presentation] 43rd Orthopedic and Trauma Congres, Buenos Aires, Argentina.  December 2006 http://www.ista.to; P16-9, p. 143

“Knee Injuries – InterX therapy to solve unresolved sport injuries”. Coleman S. [presentation] International Congress on Sports Rehabilitation and Traumatology, Bologna, Italy, 2005.

Patient Treatment Experience (120 patients treated with acute and chronic pain), Technical File for CE Mark submitted by Neuro Resource Group, Inc. ISO 13485:2003, Certification # SM88698, October 2004.

“Use of Noninvasive Interactive Neurostimulation to Improve Short-Term Recovery in Patients with Surgically Repaired Bimalleolar Ankle Fractures: A Prospective, Randomized Clinical Trial” Igor G. Gorodetskyi, MD1, Anatolyi I. Gorodnichenko, MD1, Petr S. Tursin, MD1, Vitalyi K. Reshetnyak, MD2, Oleg N. Uskov, MD3 Read abstract article…



Reference articles to study the importance of the skin impedance changes in responds to trauma, pain or inflammation

Cutaneous patterns of sympathetic activity in clinical abnormalities of the musculoskeletal system. Korr IM, Wright FM, Chace JA. In: Peterson B, ed.  The collected papers of Irvin M Korr.  American Academy of Osteopathy, Colorado, 1964:66-72.

Using localized impedance measurements to study muscle changes in injury and disease.Aaron R, Shiffman CA. Ann of the NY Ac of Sc, 2000;904:171-180.

An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle.  Jay Shah, Terry Phillips, Jerone Danoff and Lynn Gerber J Appl Physiol 99: 1977-1984, 2005

The Evaluation of Electrodermal Properties in the Identification of Myofascial Trigger Points Sarah P. Shultz, MEd, Jeffrey B. Driban, MEd, Charles B. Swanik, PhD June 2005

Biomedical Acupuncture for Pain Management; An Integrative Approach. Yun-tao Ma; Mila Ma; and Zang Hee Cho; 2005.

Trigger points and acupuncture points for pain: correlations and implications. Melzack R,Stillwell DM.; Pain. 1977 Feb;3(1):3-23.

Efficacy of electrical nerve stimulation for chronic musculoskeletal pain: a meta-analysis of randomized controlled trials.  Johnson MMartinson MPain. 2007 Jul;130(1-2):1-3. : 157-65. Epub 2007 Mar 23.

Effect of electrical stimulation on musculoskeletal systems; a meta-analysis of controlled clinical trials.  Akai MHayashi K. Bioelectromagnetics. 2002 Feb;23(2):132-43.

From the Gate to the neuromatrix  Melzack R [Department of Psycology, McGill University, Montreal, Quebec, Canada] Pain. 1999 Aug; Suppl 6:S121-6.

The neuro-immuno-cutaneous-endocrine network: relationship of the mind and skin.O’Sullivan RL, Lipper G, Lerner EA. Arch Dermatol 1998;134:1431-1435.

Fall of skin impedance and bone and joint pain. Fujita T, Fujii Y, Okada S, Miyauchi A, Takagi Y. at all Journal of bone and mineral metabolism 1988 review.

Central effect of SCENAR application:  Self-restoration of an organism through activation of the front hypothalamus.  Chebkasov SA, Bereshpolova UI SCENAR -Therapy, SCENAR Expertise, Taganrog 2000;7:15-21. (Russian)

Biomechanics of musculoskeletal pain: dynamics of the neuromatrix – Partap S. Khalsa [Department of Biomedical Engineering, State University of New York at Stony Brook, HSC T18-030 Stony Brook, NY 11794-8181,USA  Review

Skin Neuroendocreen Organ – Dirk Roosterman, Tobias Goerge, Stefan W. Schneider, Nigel W. Bunnett and Martin Steinhoff – “PDF” (1024KB)

Evaluation of Electrodermal properties in the identification of myofascial trigger points – Sarah P. Shultz, Jeffrey B. Driban, Charles B. Swanik – “PDF” (152KB)